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biotech bubble in 2000. It s true that in absolute monetary terms, venture capital investment in biotech and medical devices in 2002 was down from a high of $6.9 billion in 2000. However, prior to the bubble bursting, ven ture investment in Internet-related companies was booming and biotech companies raised $32 billion through initial public offerings (IPOs) and secondary offerings. Moreover, in relative terms, whereas venture investing in other areas fell 12 percent from 1998 to 2002, investment in biotech was up 70 percent during the same period. More recently, established pharmaceutical rms are investing in biotech in a frantic attempt to ll their pipelines with drugs, and this move is re ected in the investment com munity. Venture investing in biotechnology and medical devices totaled $4.7 billion in 2002, or about 22 percent of all venture capital investment that year, according to the MoneyTree survey by PricewaterhouseCoopers, Thomson Venture Economics, and the National Venture Capital Associa tion. This is the highest proportion in seven years, and represents a nearly fourfold increase in venture investing in biotech compared to 2000. In many ways, biotech appears poised to make a signi cant comeback as an investment vehicle and as a platform for innovation. However, the

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(8.4.19)

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(8.4.20)

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(8.4.21)

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This example assumes that the user wants to print the currently active form, so a variable is declared to retain a reference to the currently active MDI child form A rectangle is then de ned This rectangle identi es the portion of the form to be printed In this example, the entire form is printed so the rectangle begins at (0, 0) and is the size of the form The next step is to de ne the bitmap that contains a drawn image of the form The size of the bitmap is set to the full size of the form The DrawToBitmap method is a new Form method It draws the portion of the form de ned by the rectangle to a bitmap In this case, the rectangle is the size of the form so the entire form is drawn to the bitmap At this point, the bitmap is available to be printed, but it is not scaled to the size of the printer page The printer s aspect ratio is calculated by dividing the margin-bound size of the printer page height by its width The form s aspect ratio is calculated by dividing the form s height by its width If the form s aspect ratio is larger than the printer s aspect ratio, the form has a larger height so the height is set to the printer page s height and the width is scaled with the appropriate aspect ratio If the form s aspect ratio is smaller than the printer s aspect ratio, the form has a bigger width than the printer s page so the width is set to the printer page s width and the height is scaled with the appropriate aspect ratio The new rectangle is created and sized to the scaled image The DrawImage method of the PrintPageEventArgs Graphic object is called to draw the bitmap on the printed page scaled to the appropriate size The page then prints using the default printer.

For a given volume fraction f and stickiness parameter determined by solving the quadratic equation

future of biotech depends on a social and political environment receptive to the technology. The future also depends on investment by the pharma ceutical, venture capital, academic, and government communities. In vestors and innovators in the eld will have to assess the promises of biotech relative to the established biotech markets, appreciate the chal lenges faced by the pharmaceutical industry, and understand the potential demand for biotech in secondary industries. This chapter presents the economics of pharmaceuticals to give the reader an understanding of the expensive process of bringing a new drug to market. It explores the role of biotech in helping pharmaceutical rms maintain innovation, competitiveness, and continued shareholder value, whether through working with biotech companies operating as indepen dent ventures, or by acquiring the biotech they need.

12 t -

(8.4.22)

(8.4.23)

there are two real solutions for t throughout the permissible fractional volume range 0 < f < 1. Below this value there exists an intermediate range of volume fractions within which there are no real soluti ns for t. Moreover, a further condition to determine the solution of t is that Q(O) must be positive, or

Sometimes you need to create a test project from scratch For example, you may want to create the test before creating the code To build a test project from scratch: 1 Select Test | New Test from the main menu bar The Add New Test dialog is displayed (see Figure 614) 2 Select the Unit Test template If you select the Create a new Visual Basic test project option from the Add to Test Project drop-down list, the New Test Project dialog is displayed (see Figure 613) If you previously created a unit test project, you can add to it by selecting the project from the Add to Test Project drop-down list Visual Studio then adds an empty unit test class to the selected unit test project You can then skip these remaining steps

(8.4.24)

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